Safety review recordSafety records

KPV

Related names in cited records: Lys-Pro-Val

A tripeptide discussed in FDA briefing material for a 2026 pharmacy-compounding advisory-committee meeting.

Citation markers ↗ open the public records supporting the adjacent statements.

Correction · September 15, 2026

We narrowed the status wording to what the dated FDA briefing establishes. A briefing prepared for an advisory process does not establish the current absence of a later final decision. Related substance identities remain distinct. 1

This version supersedes public version 1.

Start here

The evidence at a glance

What is its status in the cited records?

FDA compounding assessment in the cited records. FDA's July 2026 briefing evaluates KPV-related bulk drug substances for pharmacy compounding. The briefing is an advisory-process assessment, not a final regulatory determination.

Status sources checked through July 29, 2026. See status sources and coverage →

Official evidence assessment

What does the official evidence assessment say?

FDA assessment dated May 12, 2026 · Read September 15, 2026 · Preserved version 1

FDA's assessment of KPV free base and KPV acetate for the nominated uses of wound healing and inflammatory conditions. The assessment was prepared for the July 2026 Pharmacy Compounding Advisory Committee meeting. FDA document ↗

What did FDA find about human studies?

FDA reported that its search did not identify studies of KPV administered to humans. It concluded that evidence was insufficient to evaluate effectiveness for the nominated uses. FDA pp. 20, 21 ↗

Why human skin research is different

FDA identified a skin-permeation study using human cadaver skin among the nomination references. That is not a study of KPV treatment in living participants. FDA pp. 20 ↗

What is known about harms?

FDA reported no identified human pharmacokinetic studies or clinical safety studies. Its adverse-event searches through December 3, 2025 did not identify qualifying reports; the agency states that potential safety risks in humans are unknown. FDA pp. 25, 26 ↗

Scope, source pin and remaining work

This summarizes the agency's dated assessment. It is not an independent claim that no evidence exists worldwide or that the briefing is a final regulatory decision. Newer reports and formulation identities require separate screening.

Source: FDA briefing document for KPV. SHA-256: 0253b86534700fc72a48cccab7b10c19201102da831ef7a8a28e8dab09fea254.

Open versioned assessment data →

Research coverage and study families

Search and screening record checked 2026-09-15. Counts describe records, not independent trials. Full-text appraisal is separate from an abstract review.

Open machine-readable coverage and record decisions →

PubMed search

Primary human administration reports for the specified molecule; other peptides, preclinical experiments and secondary reviews are separate.

128 retrieved · 0 included · 128 excluded · 0 awaiting a decision · 0 full-text appraisals

Search terms, record decisions and remaining work

"KPV"[Title/Abstract] OR "Lys-Pro-Val"[Title/Abstract]

Source retrievals and payload pins
  • Open the source endpoint ↗

    Retrieved 2026-09-15T13:04:50.086500+00:00 · HTTP 200 · SHA-256 eaa4d3fe4ab20414a5ead879b11a0179d951450d9b5a19612bbb6a32cf71f36e.

  • Open the source endpoint ↗

    Retrieved 2026-09-15T13:04:52.499645+00:00 · HTTP 200 · SHA-256 baf3e40647c186121cfab1332e29f62ac68da0eda8b7552c5f50fc58597513a1.

  • All 128 records returned by this exact title/abstract query were screened for administration of the defined KPV tripeptide to people. None met that criterion; this does not establish absence outside this query.
  • Citation follow-up, other aliases, trial registries and non-indexed reports remain separate coverage work. Preclinical evidence and related molecules require their own scopes.

Showing 25 of 128 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

  1. PubMed 42585803 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  2. PubMed 42064835 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  3. PubMed 41880199 — exclude: Secondary overview of mechanisms or potential applications; not a primary human-administration report.
  4. PubMed 41533788 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  5. PubMed 41241376 — exclude: Secondary overview of mechanisms or potential applications; not a primary human-administration report.
  6. PubMed 41209547 — exclude: Secondary overview of mechanisms or potential applications; not a primary human-administration report.
  7. PubMed 40935835 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  8. PubMed 40073467 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  9. PubMed 40030207 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  10. PubMed 39252648 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  11. PubMed 39211778 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  12. PubMed 38289234 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  13. PubMed 38041747 — exclude: Different molecule, longer sequence, acronym or name match; not administration of the defined KPV tripeptide to people.
  14. PubMed 37860176 — exclude: Different molecule, longer sequence, acronym or name match; not administration of the defined KPV tripeptide to people.
  15. PubMed 37859689 — exclude: Full-text eligibility review identifies male C57BL/6J mice in the KPV-conjugate acute and chronic colitis experiments (sections 2.5.4 and 2.5.5); not administration to people.
    Full-text eligibility check · PMC10582360

    Read the source full text ↗ · sections 2.5.4, 2.5.5.

    This reading establishes eligibility for this search; it is not a full appraisal of the study.

    Reviewed 2026-09-15; source SHA-256 7a3158245d0f6a0d4d23c128e6d9b41efb84e006120275de1deb364f466ceb1a.

  16. PubMed 37508552 — exclude: Secondary overview of mechanisms or potential applications; not a primary human-administration report.
  17. PubMed 37161053 — exclude: Different molecule, longer sequence, acronym or name match; not administration of the defined KPV tripeptide to people.
  18. PubMed 36240893 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  19. PubMed 35496263 — exclude: Different molecule, longer sequence, acronym or name match; not administration of the defined KPV tripeptide to people.
  20. PubMed 35245681 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  21. PubMed 34846053 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  22. PubMed 34662120 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  23. PubMed 34547895 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  24. PubMed 32004526 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.
  25. PubMed 31408067 — exclude: Laboratory, structural, cell/tissue or animal research in the inspected abstract; no administration of the defined KPV tripeptide to people is described.

FDA search

Active-ingredient name query in openFDA Drugs@FDA. Returned application identities include salt forms and combination products; exact indications, approval conditions, supplements and marketing status require document-level review.

0 retrieved · 0 included · 0 excluded · 0 awaiting a decision · 0 full-text appraisals

Search terms, record decisions and remaining work

products.active_ingredients.name:"KPV"

Source retrievals and payload pins
  • Open the source endpoint ↗

    Retrieved 2026-09-15T11:10:16.981646+00:00 · HTTP 404 · SHA-256 57b1e7534d003e4246182162fd2469cdf038de39405056f44fc006715e5496da.

  • Zero results describe this query response only, not absence of FDA approval or worldwide nonapproval.
  • This endpoint does not inventory every label, advisory proceeding, safety communication or regulatory document. Application inclusion does not establish current marketing or approval of every use.

Showing 0 of 0 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

    EMA search

    Local matching in the pinned EMA medicines feed; document matches also use identified EMA product numbers. This is not every national European record.

    0 retrieved · 0 included · 0 excluded · 0 awaiting a decision · 0 full-text appraisals

    Search terms, record decisions and remaining work

    Case-insensitive word-boundary identity terms: ["KPV", "Lys-Pro-Val"]

    Source retrievals and payload pins
    • Open the source endpoint ↗

      Retrieved 2026-09-15T08:34:22.905972+00:00 · HTTP 200 · SHA-256 a947c2b8a56ac2b92ec96156843f262f5e516f83b375d6791d67a8f6dc695729.

    • Document appraisal and national European sources remain open.
    • Zero matches apply only to these feed fields and terms; orphan designation is not approval.

    Showing 0 of 0 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

      EMA search

      Local matching in the pinned EMA documents feed; document matches also use identified EMA product numbers. This is not every national European record.

      0 retrieved · 0 included · 0 excluded · 0 awaiting a decision · 0 full-text appraisals

      Search terms, record decisions and remaining work

      Case-insensitive word-boundary identity terms: ["KPV", "Lys-Pro-Val"]

      Source retrievals and payload pins
      • Open the source endpoint ↗

        Retrieved 2026-09-15T08:34:29.167460+00:00 · HTTP 200 · SHA-256 c0c68d7d77783e0355cbc75bdd04772e9acc163236fc68abcd794477c4c3d439.

      • Document appraisal and national European sources remain open.
      • Zero matches apply only to these feed fields and terms; orphan designation is not approval.

      Showing 0 of 0 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

        EMA search

        Local matching in the pinned EMA orphans feed; document matches also use identified EMA product numbers. This is not every national European record.

        0 retrieved · 0 included · 0 excluded · 0 awaiting a decision · 0 full-text appraisals

        Search terms, record decisions and remaining work

        Case-insensitive word-boundary identity terms: ["KPV", "Lys-Pro-Val"]

        Source retrievals and payload pins
        • Open the source endpoint ↗

          Retrieved 2026-09-15T08:34:31.262344+00:00 · HTTP 200 · SHA-256 7448bf4e77e3345b3f3fbb7062c335d2302d8ea458a246bbe8256ce48aad2806.

        • Document appraisal and national European sources remain open.
        • Zero matches apply only to these feed fields and terms; orphan designation is not approval.

        Showing 0 of 0 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

          ClinicalTrials.gov search

          ClinicalTrials.gov name/alias discovery, including cited product names. Matches may concern combinations, background references or different formulations; identity and outcomes need screening.

          0 retrieved · 0 included · 0 excluded · 0 awaiting a decision · 0 full-text appraisals

          Search terms, record decisions and remaining work

          "KPV" OR "Lys-Pro-Val"

          Source retrievals and payload pins
          • Open the source endpoint ↗

            Retrieved 2026-09-15T11:26:15.363786+00:00 · HTTP 200 · SHA-256 b54968c05ff881a1ef7ce604b6a340248f8e2aee8637bef06da0f5693f520df8.

          • Registration is not evidence that a study succeeded, that results were published, or that a use is approved.
          • Other registries, unregistered studies and additional aliases remain outside this query.

          Showing 0 of 0 record decisions, with included studies and unresolved records first. The versioned data inventory retains every record and study-family link.

            Explore status sources, recent additions, and coverage gaps

            Living status brief

            What is the current status of KPV?

            FDA compounding assessment in the cited records. FDA's July 2026 briefing evaluates KPV-related bulk drug substances for pharmacy compounding. The briefing is an advisory-process assessment, not a final regulatory determination.

            The cited status sources were checked through July 29, 2026. This answer changes only through the profile’s visible version and correction history.

            Evidence present

            What records are connected here?

            Evidence lanes
            2
            Source years
            7
            Drugs@FDA applications
            0

            These are counts in PeptideScanner’s selected public collection, not measures of research quality, medical relevance, safety, or effectiveness.

            Coverage gaps

            What remains unknown or unsupported?

            PeptideScanner currently has no selected clinical trial records and safety records connected to this profile. That is a collection gap, not evidence that no such records exist.

            PeptideScanner does not infer an answer where the cited records do not provide one. Open the source-linked records below to inspect their scope and limits.

            Explore the Evidence Map and record counts

            Evidence Map v1

            What kinds of records connect to KPV?

            Compare collection coverage →

            This map describes PeptideScanner’s selected, source-linked collection. It is not an evidence grade and does not establish research quality, safety, effectiveness, or medical relevance.

            13Selected dated records
            20Connected citations
            7Populated source years2003–2026
            2/4Record lanes present

            Registered human studies

            Trial composition

            0 of 0 selected trial records include at least one phase value; 0 of 0 include a status value in the retained structured contract.

            PubMed bibliography

            Publication composition

            0 of 11 selected PubMed records include attributed title, venue, publication date, and publication-type fields.

            Bibliography fields unavailable here for 11 selected records; the records remain visible as metadata observations.

            Regulatory and publication surfaces

            What is structurally connected?

            Drugs@FDA applications
            0
            FDA Federal Register documents
            1
            DailyMed SPL versions
            0
            Canonical profile
            Published
            Profile structured data
            Published
            Linked dated records
            13

            Application counts reflect exact reviewed ingredient connections; Federal Register counts reflect exact reviewed peptide-name matches; DailyMed counts reflect listed SPL versions with retained ZIP receipts. “Published” describes this page’s indexing surface, not the state of scientific evidence.

            Profile publication history and record counts

            Research hub

            Explore the KPV evidence record

            Open all 13 records →
            13Dated records
            2Evidence types
            20Cited public sources
            7Source years

            Change ledger

            Recently changed for KPV

            Open all 14 events →

            PeptideScanner change dates and cited source dates stay separate. These entries report collection or version activity, not a ranking of importance.

            Record added

            Federal Register notice 2026-07361

            The Federal Register published notice 2026-07361, attributed to FDA and its parent HHS department, on 2026-04-16. Its official title is “Pharmacy Compounding Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-Bulk Drug Substances Nominated for Inclusion on the Section 503A Bulk Drug Substances List,” and PeptideScanner's exact reviewed identity mapping connects the document to BPC-157, Emideltide, Epitalon, KPV, MOTS-c, Semax and TB-500.

            PeptideScanner change date
            August 21, 2026
            Cited source date
            April 16, 2026
            Evidence lane
            Regulatory
            Record added

            PubMed record PMID 34547895

            PeptideScanner retained PubMed bibliographic metadata for PMID 34547895 at 2026-07-30T19:58:34.757Z. PubMed recorded a metadata revision date of 2021-10-21 and an Entrez history date of 2021-09-22. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            PeptideScanner change date
            August 12, 2026
            Cited source date
            October 21, 2021
            Evidence lane
            Literature metadata

            Official-source collections

            Source records for KPV

            Open the full research atlas →

            Counts and links describe PeptideScanner’s selected records. They are not rankings and do not establish research quality, safety, effectiveness, or medical relevance.

            Evidence types

            Coverage by source year

            Selected records span November 14, 2003 to July 24, 2026.

            Continue exploring

            Profiles with overlapping source-year coverage

            Open the research atlas →

            These links are based only on overlapping years and evidence lanes in PeptideScanner’s selected records. They do not imply that the peptides are medically or scientifically similar.

            Leuprolide7 shared source years215 dated records · 4 evidence typesGlucagon6 shared source years308 dated records · 4 evidence typesLiraglutide6 shared source years167 dated records · 4 evidence typesOctreotide6 shared source years160 dated records · 4 evidence types

            These dates come from selected source records and PubMed metadata. They are not a complete or continuous timeline of research, safety, approval, or effectiveness.

            Evidence summary

            What the cited records say

            FDA's July 2026 briefing evaluates KPV-related bulk drug substances for pharmacy compounding. The briefing is an advisory-process assessment, not a final regulatory determination.

            This is a source summary, not a medical recommendation. Status may differ by jurisdiction and product.

            Cited context

            Related records

            Organizations named in cited records

            • U.S. Food and Drug Administration

            Dated source history

            Updates connected to this profile

            Open the full cross-source timeline →
            1. Regulatory

              FDA committee met on seven peptide-related groups of bulk drug substances

              FDA convened its Pharmacy Compounding Advisory Committee on July 23-24, 2026, to discuss free-base and acetate bulk drug substances across seven peptide-related groups.

            2. Regulatory

              Federal Register notice 2026-07361

              The Federal Register published notice 2026-07361, attributed to FDA and its parent HHS department, on 2026-04-16. Its official title is “Pharmacy Compounding Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments-Bulk Drug Substances Nominated for Inclusion on the Section 503A Bulk Drug Substances List,” and PeptideScanner's exact reviewed identity mapping connects the document to BPC-157, Emideltide, Epitalon, KPV, MOTS-c, Semax and TB-500.

            3. Literature metadata

              PubMed record PMID 39252648

              PeptideScanner retained PubMed bibliographic metadata for PMID 39252648 at 2026-07-30T16:25:12.445Z. PubMed recorded a metadata revision date of 2026-02-17 and an Entrez history date of 2024-09-10. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            4. Literature metadata

              PubMed record PMID 27458604

              PeptideScanner retained PubMed bibliographic metadata for PMID 27458604 at 2026-07-30T18:28:30.778Z. PubMed recorded a metadata revision date of 2025-05-30 and an Entrez history date of 2016-07-27. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            5. Literature metadata

              PubMed record PMID 34846053

              PeptideScanner retained PubMed bibliographic metadata for PMID 34846053 at 2026-07-30T19:56:20.406Z. PubMed recorded a metadata revision date of 2021-12-23 and an Entrez history date of 2021-11-30. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            6. Literature metadata

              PubMed record PMID 34547895

              PeptideScanner retained PubMed bibliographic metadata for PMID 34547895 at 2026-07-30T19:58:34.757Z. PubMed recorded a metadata revision date of 2021-10-21 and an Entrez history date of 2021-09-22. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            7. Literature metadata

              PubMed record PMID 22837805

              PeptideScanner retained PubMed bibliographic metadata for PMID 22837805 at 2026-07-30T19:58:22.828Z. PubMed recorded a metadata revision date of 2021-10-21 and an Entrez history date of 2012-07-28. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            8. Literature metadata

              PubMed record PMID 25298219

              PeptideScanner retained PubMed bibliographic metadata for PMID 25298219 at 2026-07-30T20:43:08.957Z. PubMed recorded a metadata revision date of 2019-12-10 and an Entrez history date of 2014-10-10. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            9. Literature metadata

              PubMed record PMID 29953505

              PeptideScanner retained PubMed bibliographic metadata for PMID 29953505 at 2026-07-30T21:09:28.939Z. PubMed recorded a metadata revision date of 2018-12-19 and an Entrez history date of 2018-06-29. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            10. Literature metadata

              PubMed record PMID 18092346

              PeptideScanner retained PubMed bibliographic metadata for PMID 18092346 at 2026-07-30T21:10:56.892Z. PubMed recorded a metadata revision date of 2018-09-13 and an Entrez history date of 2007-12-20. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            11. Literature metadata

              PubMed record PMID 28343991

              PeptideScanner retained PubMed bibliographic metadata for PMID 28343991 at 2026-07-30T21:12:28.720Z. PubMed recorded a metadata revision date of 2018-04-05 and an Entrez history date of 2017-03-28. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.

            12. Literature metadata

              PubMed record PMID 15102092

              PeptideScanner retained PubMed bibliographic metadata for PMID 15102092 at 2026-07-30T21:56:55.933Z. PubMed recorded a metadata revision date of 2013-11-21 and an Entrez history date of 2004-04-23. PeptideScanner associated this retained record with the identity slug kpv. These dates describe PubMed metadata history, not the article's original publication date.